Vanderbilt University · SMILE Lab

Dr. Ruogu “Rena” Fang

Flowers Family Dean’s Faculty Fellow in Engineering

Department of Biomedical Engineering, Vanderbilt University

Pioneering AI-empowered precision brain health & brain-inspired AI. Ranked Top 100 worldwide in image analysis.

Dr. Ruogu Fang, Flowers Family Dean's Faculty Fellow in Engineering, Vanderbilt University
190+
Publications
$55M
Awards & Grants
10+
Years

Inside the SMILE Lab

A look inside the Smart Medical Informatics Learning and Evaluation (SMILE) Lab at Vanderbilt University.

SMILE Lab Banner

Featured In

Forbes Washington Post National Geographic ABC News Nature JAMA The Lancet

Open Positions

Postdoc: Fully funded in Medical AI, brain-inspired AI, and precision brain health.

Ph.D.: Multiple fully-funded positions in generative AI, foundation models, and digital twins.

OPS / RA / Intern: Part-time, full-time, summer, and remote research opportunities.

Learn more

The SMILE Lab

An AI researcher in medicine and healthcare, Dr. Ruogu Fang is the Flowers Family Dean’s Faculty Fellow in Engineering in the Department of Biomedical Engineering at Vanderbilt University. Her research encompasses two principal themes: AI-empowered precision brain health and brain/bio-inspired AI.

Creating groundbreaking brain and neuroscience-inspired medical AI to comprehend, diagnose, and treat brain disorders.

Her work involves addressing compelling questions, such as using machine learning techniques to quantify brain dynamics, facilitating early Alzheimer's disease diagnosis through novel imagery, predicting personalized treatment outcomes, designing precision interventions, and leveraging principles from neuroscience to develop the next generation of AI. Dr. Fang is ranked among the Top 100 (top 1%) researchers worldwide in image analysis, according to ScholarGPS.

Fang's current research is also rooted in the confluence of AI and multimodal medical image analysis. She is the PI of NIH NIA and NIMH awards (RF1AG071469 and R01MH112558), an NSF Research Initiation Initiative (CRII) Award (IIS-1564892), an NSF CISE IIS Award (IIS-1908299), and the NSF NCS-FO Award (NCS-FO-2318984), as well as a Ralph Lowe Junior Faculty Enhancement Award from Oak Ridge Associated Universities (ORAU). She has also received numerous recognitions, including selection as a Victor J. Dzau Emerging Leaders in Health and Medicine Scholar by the National Academy of Medicine, selection for the Grainger Foundation Frontiers of Engineering Symposium by the National Academy of Engineering, a Stanford Science Faculty Fellowship, selection as a Rising Star in Engineering by the Academy of Science, Engineering, and Medicine of Florida (ASEMFL), the inaugural Robin Sidhu Memorial Young Scientist Award from the Society of Brain Mapping and Therapeutics, a Best Paper Award from the IEEE International Conference on Image Processing, the University of Florida AI Course Award, a UF Herbert Wertheim College of Engineering Faculty Award for Excellence in Innovation, and UF BME Faculty Research Excellence Award and Faculty Teaching Excellence Award.

Fang's research has been featured by Forbes Magazine, The Washington Post, ABC, and RSNA. Her work has appeared in Lancet Digital Health, JAMA, PNAS, Nature Communications, Nature Computational Science, npj Digital Medicine, npj Women's Health, and top conferences such as ICCV and MICCAI. She is the President of Women in MICCAI (WiM), an Associate Editor of Medical Image Analysis, a Topic Editor of Frontiers in Human Neuroscience, a Guest Editor of Computerized Medical Imaging and Graphics, and a reviewer for The Lancet, Nature Machine Intelligence, and Science Advances. Her research has been supported by NSF, NIH, ORAU, DHS, DoD, NVIDIA, and the University of Florida. At the heart of her work is the Smart Medical Informatics Learning and Evaluation (SMILE) Lab, where she develops medical AI and deep learning models to comprehend, diagnose, and treat brain disorders while navigating extensive and intricate datasets.

Education

Ph.D. Electrical & Computer Engineering

Cornell University

B.E. Information Engineering

Zhejiang University

Latest Highlights

Latest News

08/12/2026
UK Biobank features Dr. Fang and SMILE Lab's research showing that AI analysis of routine retinal photographs can reveal modifiable Alzheimer's disease risk factors, potentially enabling earlier intervention. [UK Biobank]
08/04/2026
Our work, including "Multi-Modal Contrastive Representation Learning for Preclinical AD Prediction," "Baseline Neuroimaging and Machine Learning Predict Pain Relief Following BAT-Paired tDCS in Knee Osteoarthritis," and "Clinico-Demographic Predictors of Anxiety Treatment Response to Transcranial Direct Current Stimulation and Cognitive Training in Older Adults," will be presented at the Biomedical Engineering Society (BMES) Annual Meeting, October 21–24, 2026, in Orlando, FL!
07/31/2026
Our paper "Machine Learning and Individual Variability in Electrical Field Characteristics Predict tDCS Treatment Response for Anxiety in Older Adults in the ACT Trial" is published in Frontiers in Human Neuroscience. [Paper]
07/09/2026
Our publication "Concept2Brain: An AI model for predicting neurophysiological responses to text and pictures" is accepted for publication in Nature Communications.
06/30/2026
Dr. Fang received a new NSF BCS award (BCS-2617585) as Co-PI (PI: Odegaard), $890,113 total for “Understanding the Role of Metacognitive Sensitivity in Human-AI Joint Decision-Making.”
06/23/2026
Our paper "Emotional Responses to Naturalistic and AI-generated Affective Pictures: A Systematic Comparison" is accepted by Emotion.
06/22/2026
Our paper "Biologically Inspired Deep Neural Network Models for Visual Emotion Processing" is accepted by Network Neuroscience. Congratulations to Postdoc Dr. Liu!
06/19/2026
Congratulations to incoming SMILE Lab Ph.D. student Ethan Meidinger on receiving the 2026 NIH-MICCAI Society Registration Grant funded by R13EB35922 from the National Institute of Biomedical Imaging and Bioengineering!
06/16/2026
Dr. Fang is promoted to Full Professor by the University of Florida!
06/16/2026
UF News features Dr. Fang and SMILE Lab's research demonstrating that routine retinal photographs can help predict Alzheimer's disease risk factors years before symptoms appear. [UF News]

Affiliations

Primary

Associate Professor

Department of Biomedical Engineering, Vanderbilt University

Affiliated

Associate Professor

Department of Electrical & Computer Engineering, Vanderbilt University

Primary

Founding Director

Center for Intelligent Imaging, Vanderbilt University

Past

Tenured Associate Professor

J. Crayton Pruitt Family Dept. of Biomedical Engineering, University of Florida (2022–2026)

Visiting

Visiting Associate Professor

Stanford University, School of Medicine & Humanities and Sciences (2024–2025)

Visiting

Visiting Associate Professor

Harvard Medical School & Massachusetts General Brigham (2025)

Former Affiliated Faculty (University of Florida, through 2026)

8 appointments
  • UF Intelligent Clinical Care Center Associate Director
  • Dept. of Electrical & Computer Engineering
  • Dept. of Radiology, College of Medicine
  • Dept. of Computer & Information Science & Engineering
  • Center for Cognitive Aging and Memory
  • UF Genetics Institute
  • UF Health Cancer Center
  • Norman Fixel Institute for Neurological Diseases

Selected Honors

2025

Stanford Science Faculty Fellowship

Stanford University

2025

Doctoral Dissertation Advisor/Mentoring Award

Herbert Wertheim College of Engineering, UF

2024

NAI Senior Member

National Academy of Inventors

2024

Faculty Teaching Excellence Award

J. Crayton Pruitt Family Dept of BME, UF

2024

Pioneering Research HiPerGator Award

University of Florida Research Computing

2024

Inaugural AI Course Award

University of Florida

Professional Service

2027
Challenge Chair
MICCAI Conference
2024–
Section Editor, AI in Biomedical Engineering
Current Opinion in Biomedical Engineering
2023–2025
President, Women in MICCAI (WiM)
MICCAI Society
2022–
Area Chair
MICCAI Conference
2021–
Associate Editor
Medical Image Analysis
2015–
Editorial Board
Computerized Medical Imaging and Graphics

Reviewer For

12 venues
Nature Neuroscience npj Digital Medicine Nature Machine Intelligence The Lancet Science Advances Medical Image Analysis Scientific Data IEEE TPAMI IEEE TNNLS IEEE TMI IEEE TIP IEEE RBME

Join the SMILE Lab

We are looking for passionate researchers. Fully funded Postdoc and Ph.D. positions, plus OPS, research assistant, and internship opportunities, are available in Medical AI, brain-inspired AI, generative AI, foundation models, LLMs, and digital twins.

View Open Positions

Funding & Partners

National Institutes of Health National Science Foundation Department of Defense Department of Homeland Security NVIDIA Oak Ridge Associated Universities Oracle UF Informatics Institute Clinical and Translational Science Institute University of Florida MBRF Society for Brain Mapping and Therapeutics